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Help define the Grand Challenges for the next decade of medicine

We are looking for the hard, consequential questions. These are problems whose answers would reshape how drugs are discovered. Each contribution should state one question, explain why meaningful progress is possible, describe what answering it would enable, and define what would constitute the solution.

Anyone is welcome to submit questions, whether you are a researcher, clinician, drug developer, student, or simply someone with a deep interest in the future of drug discovery. Selected questions will be attributed to their contributors, while contact email addresses will remain private.

We value your submission. Each submission will be carefully reviewed by our scientific committee. And each officially selected question receives 100,000 Geodesic credits.

Following the selection of the official questions, we will launch a separate, dedicated call inviting everyone to propose solutions. A $1 million prize will be awarded for a verified solution to each official challenge.